chronic deficit of the hormone adrenaline

Important processes of catecholamine biosynthesis, storage, release, secretion, uptake, reuptake, degradation, and transporters in acutely or chronically stressed organisms are described.

We first provide a short overview of physiology, biochemistry, and molecular genetics of sympatho-adrenomedullary, sympatho-neural, and brain catecholaminergic systems. This serves to increase the dopamine concentration in the cerebral basal cells.Stressful stimuli evoke complex endocrine, autonomic, and behavioral responses that are extremely variable and specific depending on the type and nature of the stressors. Sitte explains that Hornykiewicz was also able to show that one cannot simply 'top up' dopamine, whereupon he developed a sort of 'precursor top-up,' Levodopa (L-Dopa), a precursor of dopamine. However, Oleh Hornykiewicz of the Center for Brain Research at MedUni Vienna has managed to explain one cause of Parkinson's disease: The working group led by the multiple award-winning scientist found a lack of dopamine in certain areas of the brain and identified it as the trigger for the disease. This can even result in mania, hallucinations or even schizophrenia.' It is not yet clear how this excessive release occurs and specific research is being conducted at MedUni Vienna to find out.

'Dopamine is the reason why a lot of people are constantly seeking to satisfy their cravings.'Īccording to Matthäus Willeit of MedUni Vienna's Department of Psychiatry and Psychotherapy, who is organising the Dopamine conference together with Harald Sitte, 'excessive dopamine release at the wrong moment can cause insignificant things to take on an unwarranted significance. 'Dopamine release is also responsible for people becoming addicted, in that they are always seeking pleasure, so that they can reach higher and higher dopamine levels,' explains Harald Sitte of MedUni Vienna's Institute of Pharmacology, speaking on the occasion of the Dopamine 2016 conference, which is taking place next week on the Vienna University campus and at MedUni Vienna's Center for Brain Research.

Chronic deficit of the hormone adrenaline